Age (years)
Patient's current age
AST (U/L)
Aspartate aminotransferase level
ALT (U/L)
Alanine aminotransferase level
Platelet Count (10⁹/L)
Number of platelets per liter
FIB-4 Index NaN — Advanced fibrosis likely (consider biopsy or imaging)
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Instructions
The Fibrosis-4 (FIB-4) Index is a non-invasive tool used to estimate the extent of liver fibrosis in patients with chronic liver disease, particularly viral hepatitis and fatty liver disease. The calculation uses four readily available clinical parameters: patient age, AST, ALT, and platelet count. By applying these values into the validated formula, the score helps identify patients at low, intermediate, or high risk for advanced fibrosis. This tool supports clinical decision-making by guiding whether patients need further imaging, non-invasive testing, or referral for biopsy.
Frequently Asked Questions
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What clinical data are needed for FIB-4?+
Can FIB-4 replace a liver biopsy?+
Is FIB-4 reliable in all populations?+
What should be done with intermediate scores?+
Can FIB-4 be used for alcohol-related liver disease?+
How often should FIB-4 be repeated?+